HSPD1

Across TCGA cell cohorts, HSPD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,006 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HSPD1-associated GO terms across cancer lineages are Ribosome biogenesis, Nucleolar large rRNA transcription by RNA polymerase I, and Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with HSPD1 in more than 17 cancer types. Because this analysis shows association rather than direction, both HSPD1-to-partner and partner-to-HSPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosome biogenesis grouped by HSPD1-low versus HSPD1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPD1→partner) and Y-score (partner→HSPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Ribosome biogenesis →	+0.139	+1.029	<.001	.001	3	18
SOFT_TISSUE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.136	+0.941	<.001	<.001	3	18
LIVER	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.107	+0.716	.003	<.001	3	18
BONE	Ribosomal large subunit biogenesis →	+0.188	+1.250	<.001	.001	3	18
BONE	'de novo' IMP biosynthetic process →	+0.223	+1.239	<.001	.001	3	18
BONE	DNA replication initiation →	+0.194	+1.054	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,006 associations by consensus.

Ribosome biogenesis by HSPD1 expression — BONE

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