HSPBP1

Across TCGA patient cohorts, HSPBP1 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPBP1-associated genes across cancer lineages are LINC01335, SGO1P1, and LINC01109. Each is linked with HSPBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPBP1-to-partner and partner-to-HSPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01335 grouped by HSPBP1-low versus HSPBP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPBP1→partner) and Y-score (partner→HSPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01335 →	+0.144	+4.513	<.001	.009	3	2
SKCM	SGO1P1 →	+0.076	+5.199	<.001	.003	3	1
SKCM	LINC01109 →	+0.051	+4.680	<.001	.007	3	1
BLCA	PLSCR5-AS1 →	+0.084	+7.640	<.001	.009	3	1
SKCM	OR10A5 →	+0.037	+4.867	<.001	.005	3	1
SKCM	NF1P3 →	+0.140	+4.771	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

LINC01335 by HSPBP1 expression — SKCM

Explore this box plot interactively →