HSPBP1

Across TCGA patient cohorts, HSPBP1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPBP1-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and Ku80. Each is linked with HSPBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPBP1-to-partner and partner-to-HSPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by HSPBP1-low versus HSPBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPBP1→partner) and Y-score (partner→HSPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.340	+3.000	.023	.037	3	1
UCEC	FOXO3a_pS318_S321 →	-0.213	-3.000	.003	.037	3	1
UCEC	Ku80 →	+0.352	+2.820	.009	.035	3	1
UCEC	MEK1_p_S217_S221 →	-0.425	-3.000	.007	.036	3	1
UCEC	Notch1 →	+0.214	+3.000	.008	.037	3	1
UCEC	p62 Lck ligand →	+0.489	+2.817	.009	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by HSPBP1 expression — UCEC

Explore this box plot interactively →