HSPBP1

Across TCGA cell cohorts, HSPBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,828 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSPBP1-associated GO terms across cancer lineages are Nucleosome disassembly, Negative regulation of calcium ion export across plasma membrane, and Transcription initiation at RNA polymerase I promoter. Each is linked with HSPBP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HSPBP1-to-partner and partner-to-HSPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleosome disassembly grouped by HSPBP1-low versus HSPBP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPBP1→partner) and Y-score (partner→HSPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nucleosome disassembly →	+0.173	+0.911	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.073	+1.020	.005	.003	2	15
STOMACH	Transcription initiation at RNA polymerase I promoter →	+0.111	+1.046	<.001	<.001	3	13
PANCREAS	DNA replication checkpoint signaling →	+0.111	+0.580	<.001	<.001	3	13
SKIN	Mitochondrial potassium ion transmembrane transport →	+0.118	+0.977	<.001	<.001	3	13
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.114	+0.706	.001	.006	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,828 associations by consensus.

Nucleosome disassembly by HSPBP1 expression — BONE

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