HSPBP1

Across TCGA cell cohorts, HSPBP1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSPBP1-associated genes across cancer lineages are DEFA4, OR13G1, and ETDC. Each is linked with HSPBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPBP1-to-partner and partner-to-HSPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by HSPBP1-low versus HSPBP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPBP1→partner) and Y-score (partner→HSPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.053	+6.022	<.001	.001	3	1
LARGE_INTESTINE	OR13G1 →	+0.032	+5.415	<.001	.004	3	1
BLOOD_Lymphoma	ETDC →	+0.521	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DEFA4 by HSPBP1 expression — LARGE_INTESTINE

Explore this box plot interactively →