HSPB7

Across TCGA pan-cancer cohorts, HSPB7 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HSPB7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HSPB7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HSPB7 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where HSPB7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPB7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−2.046	<.001	9	view →
LSCC	Female	All	−1.558	<.001	9	view →
LUAD	Female	III,IV	−1.393	<.001	9	view →
CCRCC	Male	III,IV	−0.925	<.001	7	view →
HNSC	Male	II,III,IV	−0.991	<.001	6	view →
OV	All	All	−2.426	<.001	2	view →
PDAC	All	All	+0.344	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HSPB7–COAD

Open the COAD breakdown →