HSPB7

Across TCGA patient cohorts, HSPB7 mutation is significantly associated with the RNA expression of many other genes, with 196 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HSPB7-associated genes across cancer lineages are MTND5P24, SNX18P27, and RN7SL383P. Each is linked with HSPB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPB7-to-partner and partner-to-HSPB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P24 grouped by HSPB7-low versus HSPB7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB7→partner) and Y-score (partner→HSPB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTND5P24 →	+0.180	+4.372	<.001	<.001	3	2
COAD	SNX18P27 →	+0.465	+4.070	<.001	.009	3	2
COAD	RN7SL383P →	+0.595	+5.087	<.001	.002	3	2
COAD	NTF6A →	+0.720	+5.831	<.001	<.001	3	2
COAD	TAAR1 →	+0.598	+3.096	<.001	.007	3	2
UCEC	RNU4-14P →	+0.398	+3.016	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 196 associations by consensus.

MTND5P24 by HSPB7 expression — COAD

Explore this box plot interactively →