HSPB3

Across TCGA cell cohorts, HSPB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,618 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HSPB3-associated GO terms across cancer lineages are Regulation of extracellular matrix disassembly, Negative regulation of amino acid biosynthetic process, and Negative regulation of amino acid metabolic process. Each is linked with HSPB3 in more than 5 cancer types. Because this analysis shows association rather than direction, both HSPB3-to-partner and partner-to-HSPB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of extracellular matrix disassembly grouped by HSPB3-low versus HSPB3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB3→partner) and Y-score (partner→HSPB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of extracellular matrix disassembly →	+0.124	+1.475	<.001	.005	3	6
BONE	Negative regulation of amino acid biosynthetic process →	+0.353	+2.136	<.001	<.001	3	6
BONE	Negative regulation of amino acid metabolic process →	+0.353	+2.136	<.001	<.001	3	6
SKIN	Thiamine transport →	-0.813	-0.911	<.001	.002	3	6
BONE	Regulation of neuron apoptotic process →	+0.078	+1.572	<.001	<.001	3	6
SKIN	Thiamine transmembrane transport →	-0.953	-1.292	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,618 associations by consensus.

Regulation of extracellular matrix disassembly by HSPB3 expression — SOFT_TISSUE

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