HSPB2

Across TCGA patient cohorts, HSPB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,166 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HSPB2-associated GO terms across cancer lineages are Negative regulation of amyloid fibril formation, Aorta development, and Smooth muscle cell-matrix adhesion. Each is linked with HSPB2 in more than 24 cancer types. Because this analysis shows association rather than direction, both HSPB2-to-partner and partner-to-HSPB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of amyloid fibril formation grouped by HSPB2-low versus HSPB2-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPB2→partner) and Y-score (partner→HSPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Negative regulation of amyloid fibril formation →	+0.073	+0.642	<.001	<.001	3	25
SCLC	Aorta development →	+0.133	+0.889	<.001	<.001	3	23
SCLC	Smooth muscle cell-matrix adhesion →	+0.402	+1.000	<.001	<.001	3	22
SCLC	Extracellular matrix assembly →	+0.113	+0.875	<.001	<.001	3	22
SCLC	Regulation of macrophage migration →	+0.207	+0.805	<.001	<.001	3	22
SCLC	Membrane raft assembly →	+0.124	+0.605	.001	.002	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

Negative regulation of amyloid fibril formation by HSPB2 expression — PAAD

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