HSPB1

Across TCGA pan-cancer cohorts, HSPB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HSPB1 data layer compared with 30 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSPB1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HSPB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where HSPB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	1.000	0.954	.023	21	view →
GBM	DFS	Tertile	All	0.549	0.925	<.001	21	view →
CCRCC	DFS	Quartile	All	0.533	0.947	.001	18	view →
LSCC	DFS	Median	II,III,IV	1.000	0.824	.002	13	view →
LUAD	OS	Tertile	II,III,IV	0.730	0.245	.017	4	view →
PDAC	DFS	Quartile	All	0.875	0.748	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HSPB1–HNSC (OS)

Open the HNSC breakdown →