HSPA9

Across TCGA pan-cancer cohorts, HSPA9 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HSPA9 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HSPA9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPA9 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where HSPA9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.564	0.910	.001	37	view →
LSCC	DFS	Median	II,III,IV	1.000	0.833	.004	7	view →
LUAD	DFS	Tertile	All	0.480	0.714	.036	7	view →
UCEC	OS	Median	II,III,IV	1.000	0.675	.030	4	view →
HNSC	OS	Median	All	1.000	0.960	.026	4	view →
GBM	OS	Tertile	All	0.855	0.775	.040	2	view →
PDAC	OS	Quartile	II,III,IV	0.793	0.930	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HSPA9–CCRCC (DFS)

Open the CCRCC breakdown →