Across TCGA pan-cancer cohorts, HSPA8P18 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HSPA8P18’s most consistent transcriptional readouts.
The strongest signal is observed in prostate adenocarcinoma (PRAD), where HSPA8P18 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPA8P18 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
PRAD, KICH, and LIHC are the cancer types where HSPA8P18 tumor–normal differential expression is most reproducible.