HSPA8

Across TCGA pan-cancer cohorts, HSPA8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HSPA8 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSPA8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HSPA8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where HSPA8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.837	0.622	.007	34	view →
CCRCC	OS	Median	III,IV	0.468	0.827	.002	27	view →
PDAC	DFS	Tertile	All	0.518	0.331	.003	19	view →
GBM	DFS	Median	All	0.257	0.483	.002	10	view →
LSCC	DFS	Quartile	II,III,IV	0.892	0.513	.010	6	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.617	.037	4	view →
LUAD	DFS	Median	All	0.677	0.944	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HSPA8–HNSC (OS)

Open the HNSC breakdown →