HSPA8

Across TCGA patient cohorts, HSPA8 mutation is significantly associated with the RNA expression of many other genes, with 3,907 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA8-associated genes across cancer lineages are OR5F2P, GRSF1, and RNU6ATAC30P. Each is linked with HSPA8 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSPA8-to-partner and partner-to-HSPA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5F2P grouped by HSPA8-low versus HSPA8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA8→partner) and Y-score (partner→HSPA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR5F2P →	+0.147	+5.734	<.001	<.001	3	3
UCEC	GRSF1 →	+0.485	+2.280	<.001	<.001	3	3
UCEC	RNU6ATAC30P →	+0.213	+1.599	.008	.008	3	3
UCEC	PCGF6 →	+0.472	+2.102	.002	.001	3	3
UCEC	TATDN2 →	+0.314	+2.091	.001	.001	3	3
UCEC	BZW1 →	+0.605	+2.470	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,907 associations by consensus.

OR5F2P by HSPA8 expression — COAD

Explore this box plot interactively →