HSPA8

Across TCGA cell cohorts, HSPA8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,464 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HSPA8-associated GO terms across cancer lineages are DNA replication initiation, rRNA processing, and Positive regulation of chromosome condensation. Each is linked with HSPA8 in more than 18 cancer types. Because this analysis shows association rather than direction, both HSPA8-to-partner and partner-to-HSPA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by HSPA8-low versus HSPA8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA8→partner) and Y-score (partner→HSPA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.197	+1.649	<.001	<.001	3	19
BONE	rRNA processing →	+0.126	+0.780	<.001	.001	3	17
OESOPHAGUS	Positive regulation of chromosome condensation →	+0.171	+0.908	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Maturation of SSU-rRNA →	+0.120	+1.138	.007	.005	2	17
OESOPHAGUS	DNA replication →	+0.130	+1.144	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Transcription by RNA polymerase I →	+0.137	+1.572	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,464 associations by consensus.

DNA replication initiation by HSPA8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →