HSPA4

Across TCGA pan-cancer cohorts, HSPA4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HSPA4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HSPA4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPA4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where HSPA4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.908	1.000	.009	24	view →
PDAC	DFS	Quartile	II,III,IV	0.518	0.254	.021	19	view →
LUAD	DFS	Quartile	All	0.394	0.891	.004	16	view →
UCEC	OS	Median	II,III,IV	1.000	0.675	.030	16	view →
HNSC	OS	Median	All	0.993	0.941	.028	9	view →
LSCC	DFS	Median	II,III,IV	1.000	0.839	.006	6	view →
CCRCC	DFS	Tertile	III,IV	0.545	0.847	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HSPA4–COAD (DFS)

Open the COAD breakdown →