HSPA4

Across TCGA patient cohorts, HSPA4 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA4-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and 53BP1. Each is linked with HSPA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA4-to-partner and partner-to-HSPA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by HSPA4-low versus HSPA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA4→partner) and Y-score (partner→HSPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.138	+1.289	.025	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.416	+1.522	.028	.017	3	2
UCEC	53BP1 →	+0.241	+2.000	.027	.029	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.584	.001	.001	3	1
UCEC	eIF4E →	+0.172	+2.247	.010	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-3.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ERK2 by HSPA4 expression — UCEC

Explore this box plot interactively →