HSPA4

Across TCGA cell cohorts, HSPA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,554 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HSPA4-associated GO terms across cancer lineages are DNA-templated DNA replication, Positive regulation of rRNA processing, and DNA replication. Each is linked with HSPA4 in more than 15 cancer types. Because this analysis shows association rather than direction, both HSPA4-to-partner and partner-to-HSPA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by HSPA4-low versus HSPA4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA4→partner) and Y-score (partner→HSPA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA-templated DNA replication →	+0.124	+0.716	<.001	.004	3	16
BLOOD_Lymphoma	Positive regulation of rRNA processing →	+0.134	+0.774	<.001	<.001	3	15
URINARY_TRACT	DNA replication →	+0.092	+0.804	.003	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.171	+1.067	<.001	<.001	3	13
OESOPHAGUS	Maturation of SSU-rRNA →	+0.152	+0.920	.001	<.001	3	13
LUNG_SCLC	Ribosomal small subunit biogenesis →	+0.093	+0.779	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,554 associations by consensus.

DNA-templated DNA replication by HSPA4 expression — OESOPHAGUS

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