HSPA2

Across TCGA patient cohorts, HSPA2 mutation is significantly associated with the RNA expression of many other genes, with 6,512 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA2-associated genes across cancer lineages are SRP54, PSMD9, and COPS3. Each is linked with HSPA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HSPA2-to-partner and partner-to-HSPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP54 grouped by HSPA2-low versus HSPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA2→partner) and Y-score (partner→HSPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SRP54 →	+0.534	+2.235	<.001	<.001	3	4
COAD	PSMD9 →	+0.329	+3.595	<.001	.001	3	4
UCEC	COPS3 →	+0.514	+1.954	<.001	<.001	3	4
UCEC	PRMT5 →	+0.625	+3.917	<.001	<.001	3	3
UCEC	GNPNAT1 →	+0.712	+2.203	<.001	<.001	3	3
UCEC	CDKN3 →	+0.772	+3.140	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,512 associations by consensus.

SRP54 by HSPA2 expression — UCEC

Explore this box plot interactively →