HSPA2

Across TCGA cell cohorts, HSPA2 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSPA2-associated genes across cancer lineages are CST4, NPHS2, and CLEC14A. Each is linked with HSPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA2-to-partner and partner-to-HSPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST4 grouped by HSPA2-low versus HSPA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA2→partner) and Y-score (partner→HSPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CST4 →	+0.397	+3.453	<.001	.009	3	2
URINARY_TRACT	NPHS2 →	+0.187	+5.044	<.001	<.001	3	1
URINARY_TRACT	CLEC14A →	+0.013	+4.217	.007	.005	3	1
URINARY_TRACT	TMEM252 →	+0.637	+4.217	<.001	.005	3	1
URINARY_TRACT	PRR23A →	+0.028	+4.584	<.001	.002	3	1
CNS	F9 →	+0.022	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

CST4 by HSPA2 expression — SKIN

Explore this box plot interactively →