Across TCGA pan-cancer cohorts, HSPA1L Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HSPA1L data layer compared with 27 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher HSPA1L Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSPA1L expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, UCEC, and READ are the cancer types where HSPA1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	27	view →
UCEC	DFS	Median	All	0.964	0.624	.011	26	view →
READ	DFS	Median	III,IV	0.059	0.761	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HSPA1L tumor-vs-normal RNA expression · all HSPA1L data types