Across TCGA pan-cancer cohorts, HSPA1L mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HSPA1L data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSPA1L mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HSPA1L expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where HSPA1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.870	0.551	.019	18	view →
LUAD	DFS	Tertile	III,IV	0.632	1.000	.001	11	view →
CCRCC	DFS	Median	All	0.905	0.652	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HSPA1L tumor-vs-normal RNA expression · all HSPA1L data types