Across TCGA patient cohorts, HSPA1L mutation is significantly associated with the RNA expression of many other genes, with 3,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA1L-associated genes across cancer lineages are AP2B1, RNU7-29P, and PITPNM3. Each is linked with HSPA1L in more than 3 cancer types. Because this analysis shows association rather than direction, both HSPA1L-to-partner and partner-to-HSPA1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA1L→partner) and Y-score (partner→HSPA1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AP2B1 →	+0.427	+2.884	.002	.001	3	4
BRCA	RNU7-29P →	+0.395	+8.055	<.001	.007	3	3
COAD	PITPNM3 →	+0.739	+3.321	<.001	.009	3	3
SKCM	E2F6P1 →	+0.017	+2.688	<.001	.004	3	3
HNSC	AMMECR1-IT1 →	+0.104	+3.260	<.001	.009	3	3
READ	MTND5P8 →	+0.090	+5.219	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,450 associations by consensus.

Exploration

HSPA1L survival (RNA) · tumor vs normal (RNA) · all HSPA1L data types