HSPA1L

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HSPA1L mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA1L-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and INPP4B. Each is linked with HSPA1L in more than 2 cancer types. Because this analysis shows association rather than direction, both HSPA1L-to-partner and partner-to-HSPA1L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA1L→partner) and Y-score (partner→HSPA1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-7-cleavedD198 →+0.655+2.242.003.00533
UCECEGFR_pY1068 →-0.330-3.321<.001<.00132
COADINPP4B →-0.372-3.000.021.03432
UCECJNK_pT183_Y185 →-0.173-2.000.006.00932
COADShc_pY317 →-0.185-2.450.010.02032
UCECASNS →+0.419+2.000.001.03032
Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

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