Across TCGA pan-cancer cohorts, HSPA1A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HSPA1A data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSPA1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HSPA1A expression acts as an unfavorable survival marker.

HNSC, KICH, and ESCA are the cancer types where HSPA1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.010	0.757	<.001	36	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ESCA	DFS	Median	II,III,IV	0.080	0.523	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HSPA1A tumor-vs-normal RNA expression · all HSPA1A data types