Across TCGA patient cohorts, HSPA1A mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA1A-associated genes across cancer lineages are 14-3-3_beta, Ku80, and MEK1. Each is linked with HSPA1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA1A-to-partner and partner-to-HSPA1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA1A→partner) and Y-score (partner→HSPA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.102	-3.143	.035	.018	3	1
UCEC	Ku80 →	+0.308	+2.472	.006	.011	3	1
UCEC	MEK1 →	+0.372	+3.000	.035	.036	3	1
UCEC	p62 Lck ligand →	+0.381	+2.459	.015	.020	3	1
UCEC	Bim →	-0.283	-3.000	.025	.036	3	1
UCEC	c-Met_pY1235 →	+0.099	+2.179	.005	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

HSPA1A survival (RNA) · tumor vs normal (RNA) · all HSPA1A data types