Across TCGA cell cohorts, HSPA1A mutation is significantly associated with the mutation status of many other genes, with 14 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HSPA1A-associated genes across cancer lineages are BRICD5, CCHCR1, and GLI4. Each is linked with HSPA1A in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA1A-to-partner and partner-to-HSPA1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA1A→partner) and Y-score (partner→HSPA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BRICD5 →	+4.459	+5.277	.005	.005	1	1
CNS	CCHCR1 →	+4.044	+5.000	.008	.008	1	1
CNS	GLI4 →	+6.044	+6.044	.001	.001	1	1
CNS	NT5C1B-RDH14 →	+6.044	+6.044	.001	.001	1	1
CNS	PIK3IP1 →	+6.044	+6.044	.001	.001	1	1
CNS	STIM2 →	+4.044	+5.000	.008	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

HSPA1A survival (RNA) · tumor vs normal (RNA) · all HSPA1A data types