Across TCGA pan-cancer cohorts, HSPA14 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of HSPA14’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HSPA14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HSPA14 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
KIRC, BLCA, and THCA are the cancer types where HSPA14 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HSPA14 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.