HSPA13

Across TCGA cell cohorts, HSPA13 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,713 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSPA13-associated GO terms across cancer lineages are ERAD pathway, Vesicle cargo loading, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with HSPA13 in more than 13 cancer types. Because this analysis shows association rather than direction, both HSPA13-to-partner and partner-to-HSPA13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by HSPA13-low versus HSPA13-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA13→partner) and Y-score (partner→HSPA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ERAD pathway →	+0.133	+1.560	<.001	<.001	3	14
STOMACH	Vesicle cargo loading →	+0.120	+1.074	.002	.007	3	13
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.116	+1.550	<.001	<.001	3	13
BONE	COPII-coated vesicle cargo loading →	+0.119	+0.900	<.001	<.001	3	12
BLOOD_Myeloma	Endoplasmic reticulum mannose trimming →	+0.116	+1.215	<.001	<.001	3	12
BONE	Positive regulation of retrograde protein transport, ER to cytosol →	+0.138	+0.910	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,713 associations by consensus.

ERAD pathway by HSPA13 expression — BLOOD_Myeloma

Explore this box plot interactively →