HSPA12B

Across TCGA patient cohorts, HSPA12B mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSPA12B-associated genes across cancer lineages are p70-S6K_pT389, C-Raf, and INPP4B. Each is linked with HSPA12B in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA12B-to-partner and partner-to-HSPA12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by HSPA12B-low versus HSPA12B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA12B→partner) and Y-score (partner→HSPA12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p70-S6K_pT389 →	-0.162	-2.321	.048	.035	3	2
SKCM	C-Raf →	+0.166	+2.824	.016	.034	3	2
UCEC	INPP4B →	-0.371	-3.584	.004	.002	3	2
UCEC	Akt_pT308 →	+0.537	+2.321	.034	.033	3	2
SKCM	ER-alpha →	-0.237	-3.459	.010	.005	3	1
SKCM	G6PD →	-0.226	-2.321	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

p70-S6K_pT389 by HSPA12B expression — SKCM

Explore this box plot interactively →