HSPA12B

Across TCGA cell cohorts, HSPA12B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,705 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSPA12B-associated GO terms across cancer lineages are Negative regulation of chromosome organization, IMP biosynthetic process, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with HSPA12B in more than 9 cancer types. Because this analysis shows association rather than direction, both HSPA12B-to-partner and partner-to-HSPA12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome organization grouped by HSPA12B-low versus HSPA12B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA12B→partner) and Y-score (partner→HSPA12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of chromosome organization →	+0.080	+0.583	<.001	.001	3	9
BREAST	IMP biosynthetic process →	+0.138	+0.374	<.001	<.001	3	9
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.123	+0.863	<.001	.003	2	10
STOMACH	Tissue homeostasis →	-0.069	-0.406	.003	.004	2	9
STOMACH	Anatomical structure homeostasis →	-0.069	-0.406	.003	.004	2	9
LARGE_INTESTINE	Protein depolymerization →	+0.108	+0.584	<.001	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,705 associations by consensus.

Negative regulation of chromosome organization by HSPA12B expression — BONE

Explore this box plot interactively →