HSPA12B

Across TCGA cell cohorts, HSPA12B mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSPA12B-associated genes across cancer lineages are APOL5, HHLA1, and MAGEL2. Each is linked with HSPA12B in more than 1 cancer types. Because this analysis shows association rather than direction, both HSPA12B-to-partner and partner-to-HSPA12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOL5 grouped by HSPA12B-low versus HSPA12B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSPA12B→partner) and Y-score (partner→HSPA12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOL5 →	+0.014	+4.060	<.001	.003	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MAGEL2 →	+0.527	+4.133	<.001	.003	3	1
LARGE_INTESTINE	AVP →	+0.056	+3.632	<.001	.003	3	1
LARGE_INTESTINE	G6PC2 →	+0.031	+3.658	.001	.005	3	1
LARGE_INTESTINE	ELOA3DP →	+0.030	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

APOL5 by HSPA12B expression — BLOOD_Leukemia

Explore this box plot interactively →