HSP90B1

Across TCGA pan-cancer cohorts, HSP90B1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HSP90B1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HSP90B1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HSP90B1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, GBM, and LUAD are the cancer types where HSP90B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.591	1.000	<.001	36	view →
GBM	DFS	Tertile	All	0.205	0.462	.003	12	view →
LUAD	DFS	Median	III,IV	0.732	0.263	.015	5	view →
LSCC	DFS	Median	All	1.000	0.597	.006	5	view →
PDAC	DFS	Quartile	II,III,IV	0.881	0.649	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HSP90B1–CCRCC (OS)

Open the CCRCC breakdown →