HSP90B1

Across TCGA patient cohorts, HSP90B1 mutation is significantly associated with the RNA expression of many other genes, with 3,132 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSP90B1-associated genes across cancer lineages are MBD2, IER3IP1, and BUB3. Each is linked with HSP90B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSP90B1-to-partner and partner-to-HSP90B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD2 grouped by HSP90B1-low versus HSP90B1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90B1→partner) and Y-score (partner→HSP90B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MBD2 →	+0.408	+3.625	.006	.001	3	3
COAD	IER3IP1 →	+0.624	+3.598	<.001	.001	3	3
UCEC	BUB3 →	+0.539	+3.162	<.001	<.001	3	3
UCEC	PDGFD →	-0.741	-1.756	<.001	.002	3	3
UCEC	RN7SL591P →	+0.070	+3.294	<.001	<.001	3	3
READ	FOXO1B →	+0.146	+5.039	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,132 associations by consensus.

MBD2 by HSP90B1 expression — COAD

Explore this box plot interactively →