HSP90B1

Across TCGA patient cohorts, HSP90B1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSP90B1-associated genes across cancer lineages are ATM, eIF4E, and Di-Ras3. Each is linked with HSP90B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSP90B1-to-partner and partner-to-HSP90B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HSP90B1-low versus HSP90B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90B1→partner) and Y-score (partner→HSP90B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.581	-2.070	<.001	.001	3	3
UCEC	eIF4E →	+0.144	+1.736	.049	.007	3	2
UCEC	Di-Ras3 →	-0.165	-2.794	.001	.003	3	2
COAD	XBP1 →	+0.190	+3.330	.034	.005	3	2
COAD	ASNS →	+0.659	+3.169	<.001	.018	3	2
COAD	Cyclin-E2 →	+0.216	+3.025	.047	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ATM by HSP90B1 expression — UCEC

Explore this box plot interactively →