HSP90B1

Across TCGA cell cohorts, HSP90B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,818 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSP90B1-associated GO terms across cancer lineages are Positive regulation of protein exit from endoplasmic reticulum, Protein folding in endoplasmic reticulum, and Cotranslational protein targeting to membrane. Each is linked with HSP90B1 in more than 14 cancer types. Because this analysis shows association rather than direction, both HSP90B1-to-partner and partner-to-HSP90B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein exit from endoplasmic reticulum grouped by HSP90B1-low versus HSP90B1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90B1→partner) and Y-score (partner→HSP90B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of protein exit from endoplasmic reticulum →	+0.123	+0.563	.004	.001	2	15
SKIN	Protein folding in endoplasmic reticulum →	+0.062	+0.672	<.001	<.001	3	14
SKIN	Cotranslational protein targeting to membrane →	+0.083	+0.677	<.001	<.001	3	13
BONE	Glycoprotein biosynthetic process →	+0.048	+0.887	.001	<.001	2	14
BLOOD_Lymphoma	Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway →	+0.199	+1.427	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Post-translational protein targeting to membrane, translocation →	+0.088	+0.675	.003	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,818 associations by consensus.

Positive regulation of protein exit from endoplasmic reticulum by HSP90B1 expression — LIVER

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