HSP90B1

Across TCGA cell cohorts, HSP90B1 mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HSP90B1-associated genes across cancer lineages are KLF18, PRRT1B, and AMELX. Each is linked with HSP90B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSP90B1-to-partner and partner-to-HSP90B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF18 grouped by HSP90B1-low versus HSP90B1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90B1→partner) and Y-score (partner→HSP90B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KLF18 →	+0.006	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	PRRT1B →	+0.025	+4.209	<.001	.006	3	1
BLOOD_Leukemia	AMELX →	+0.033	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TEX26 →	+0.023	+4.539	<.001	.007	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
CNS	AQP12A →	+0.040	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

KLF18 by HSP90B1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →