Across TCGA pan-cancer cohorts, HSP90AB3P Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HSP90AB3P data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HSP90AB3P Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HSP90AB3P expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, LUAD, and LIHC are the cancer types where HSP90AB3P Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.202	0.744	<.001	42	view →
LUAD	OS	Median	All	0.220	0.837	<.001	12	view →
LIHC	OS	Median	All	0.507	0.777	.017	6	view →
SKCM	OS	Median	All	0.972	0.867	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: HSP90AB3P tumor-vs-normal RNA expression · all HSP90AB3P data types