Across TCGA pan-cancer cohorts, HSP90AB2P Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HSP90AB2P data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HSP90AB2P Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HSP90AB2P expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUAD, and SKCM are the cancer types where HSP90AB2P Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.620	.011	22	view →
LUAD	OS	Median	III,IV	0.158	0.663	.008	12	view →
SKCM	DFS	Median	All	0.205	0.646	<.001	11	view →
CHOL	OS	Median	All	0.154	0.793	.004	9	view →
LUSC	DFS	Median	III,IV	0.207	0.646	.007	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HSP90AB2P tumor-vs-normal RNA expression · all HSP90AB2P data types