Across TCGA patient cohorts, HSP90AB2P mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSP90AB2P-associated genes across cancer lineages are ATM, c-Met_pY1235, and Cyclin-E2. Each is linked with HSP90AB2P in more than 1 cancer types. Because this analysis shows association rather than direction, both HSP90AB2P-to-partner and partner-to-HSP90AB2P results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AB2P→partner) and Y-score (partner→HSP90AB2P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.457	-2.807	.021	.003	3	2
UCEC	c-Met_pY1235 →	+0.087	+3.331	.007	.005	3	2
UCEC	Cyclin-E2 →	+0.186	+3.179	.011	.010	3	2
LUSC	S6_pS240_S244 →	-0.658	-3.000	.006	.035	2	2
UCEC	EGFR_pY1068 →	-0.229	-2.321	.037	.034	3	1
UCEC	EGFR_pY1173 →	+0.081	+1.611	.020	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

HSP90AB2P survival (RNA) · tumor vs normal (RNA) · all HSP90AB2P data types