HSP90AB1

Across TCGA pan-cancer cohorts, HSP90AB1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HSP90AB1 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HSP90AB1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HSP90AB1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, BRCA, and SKCM are the cancer types where HSP90AB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.848	0.606	.022	19	view →
BRCA	OS	Median	II,III,IV	0.739	0.958	.001	18	view →
SKCM	OS	Median	All	0.230	0.781	.004	16	view →
UCEC	DFS	Median	All	0.954	0.827	.018	12	view →
LUSC	DFS	Median	II,III,IV	0.210	0.715	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HSP90AB1–BLCA (DFS)

Open the BLCA breakdown →