HSP90AB1

Across TCGA pan-cancer cohorts, HSP90AB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HSP90AB1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HSP90AB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HSP90AB1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where HSP90AB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.513	0.891	<.001	63	view →
LSCC	DFS	Tertile	All	0.853	0.595	.008	22	view →
GBM	OS	Median	All	0.714	0.347	.001	14	view →
LUAD	DFS	Median	All	0.647	0.957	.007	7	view →
PDAC	DFS	Tertile	All	0.199	0.422	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HSP90AB1–CCRCC (DFS)

Open the CCRCC breakdown →