HSP90AB1

Across TCGA patient cohorts, HSP90AB1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,117 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HSP90AB1-associated proteins across cancer lineages are XPO5, MSH2, and BOP1. Each is linked with HSP90AB1 in more than 7 cancer types. Because this analysis shows association rather than direction, both HSP90AB1-to-partner and partner-to-HSP90AB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HSP90AB1 versus XPO5 in LSCC, with a Pearson correlation of 0.79.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AB1→partner) and Y-score (partner→HSP90AB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO5 →	+0.689	+0.777	<.001	<.001	3	8
LSCC	MSH2 →	+0.724	+0.904	<.001	<.001	3	6
LSCC	BOP1 →	+0.265	+0.650	<.001	<.001	3	5
LUAD	BRIX1 →	+0.366	+0.335	<.001	<.001	3	5
LSCC	CDK1 →	+0.805	+0.696	<.001	<.001	3	5
LSCC	DHX9 →	+0.199	+0.583	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,117 associations by consensus.

HSP90AB1 vs XPO5 — LSCC

Explore this scatter interactively →