HSP90AB1

Across TCGA patient cohorts, HSP90AB1 mutation is significantly associated with the RNA expression of many other genes, with 3,594 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSP90AB1-associated genes across cancer lineages are RNF19BPY, MIR6754, and LINC02706. Each is linked with HSP90AB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HSP90AB1-to-partner and partner-to-HSP90AB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF19BPY grouped by HSP90AB1-low versus HSP90AB1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AB1→partner) and Y-score (partner→HSP90AB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNF19BPY →	+0.012	+7.473	<.001	.007	3	3
BRCA	MIR6754 →	+0.443	+4.883	<.001	.006	3	2
BLCA	LINC02706 →	+0.042	+4.311	<.001	.004	3	2
BLCA	MIR6729 →	+0.138	+3.985	<.001	.007	3	2
READ	RNU6-271P →	+0.592	+5.653	<.001	.003	3	2
READ	RNA5SP19 →	+1.003	+5.039	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,594 associations by consensus.

RNF19BPY by HSP90AB1 expression — BRCA

Explore this box plot interactively →