HSP90AB1

Across TCGA patient cohorts, HSP90AB1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSP90AB1-associated genes across cancer lineages are ER-alpha_pS118, Cyclin-B1, and Ku80. Each is linked with HSP90AB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSP90AB1-to-partner and partner-to-HSP90AB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by HSP90AB1-low versus HSP90AB1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AB1→partner) and Y-score (partner→HSP90AB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ER-alpha_pS118 →	+0.169	+3.321	.003	.010	3	2
UCEC	Cyclin-B1 →	+0.586	+2.432	<.001	<.001	3	2
UCEC	Ku80 →	+0.231	+1.150	.001	.028	3	2
UCEC	Tuberin →	+0.285	+1.584	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.513	+1.434	.006	.027	3	2
UCEC	53BP1 →	+0.239	+2.459	.026	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ER-alpha_pS118 by HSP90AB1 expression — BLCA

Explore this box plot interactively →