HSP90AB1

Across TCGA cell cohorts, HSP90AB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,703 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HSP90AB1-associated GO terms across cancer lineages are DNA replication initiation, Maturation of SSU-rRNA, and Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with HSP90AB1 in more than 18 cancer types. Because this analysis shows association rather than direction, both HSP90AB1-to-partner and partner-to-HSP90AB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by HSP90AB1-low versus HSP90AB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AB1→partner) and Y-score (partner→HSP90AB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.226	+0.744	<.001	<.001	1	19
OESOPHAGUS	Maturation of SSU-rRNA →	+0.140	+0.888	<.001	.004	2	18
OESOPHAGUS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.151	+0.921	<.001	.004	3	17
OESOPHAGUS	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.124	+0.908	.005	.005	3	17
LARGE_INTESTINE	Transcription initiation at RNA polymerase I promoter →	+0.142	+0.751	<.001	<.001	3	16
PANCREAS	rRNA processing →	+0.110	+1.163	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,703 associations by consensus.

DNA replication initiation by HSP90AB1 expression — BONE

Explore this box plot interactively →