HSP90AB1

Across TCGA cell cohorts, HSP90AB1 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSP90AB1-associated genes across cancer lineages are UNC45B, VCY1B, and VCY. Each is linked with HSP90AB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSP90AB1-to-partner and partner-to-HSP90AB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC45B grouped by HSP90AB1-low versus HSP90AB1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AB1→partner) and Y-score (partner→HSP90AB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UNC45B →	+0.006	+5.087	<.001	.004	3	2
OVARY	VCY1B →	+0.294	+4.029	<.001	.009	3	1
OVARY	VCY →	+0.297	+4.228	<.001	.006	3	1
OVARY	TRAT1 →	+0.017	+4.029	.005	.009	3	1
LARGE_INTESTINE	IRGC →	+0.072	+3.509	<.001	.008	3	1
LARGE_INTESTINE	TTLL8 →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

UNC45B by HSP90AB1 expression — URINARY_TRACT

Explore this box plot interactively →