HSP90AA1

Across TCGA pan-cancer cohorts, HSP90AA1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HSP90AA1 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher HSP90AA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HSP90AA1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

SARC, UCEC, and KIRP are the cancer types where HSP90AA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.127	0.860	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
KIRP	OS	Median	All	0.270	0.903	.012	3	view →
STAD	OS	Median	III,IV	0.153	0.629	.014	3	view →
BLCA	OS	Median	III,IV	0.882	0.642	.043	3	view →
LUAD	OS	Median	All	0.188	0.670	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HSP90AA1–SARC (OS)

Open the SARC breakdown →