HSP90AA1

Across TCGA patient cohorts, HSP90AA1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HSP90AA1-associated genes across cancer lineages are 4E-BP1, Annexin-1, and Cyclin-B1. Each is linked with HSP90AA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HSP90AA1-to-partner and partner-to-HSP90AA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by HSP90AA1-low versus HSP90AA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AA1→partner) and Y-score (partner→HSP90AA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.272	+2.199	.021	.033	3	2
BLCA	Annexin-1 →	+0.464	+1.999	.032	.031	3	1
SKCM	Cyclin-B1 →	+0.641	+3.169	.003	.019	3	1
UCEC	ERK2 →	+0.204	+2.321	.015	.034	3	1
UCEC	JNK2 →	+0.281	+1.763	.001	.048	3	1
UCEC	MEK1 →	+0.482	+2.807	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

4E-BP1 by HSP90AA1 expression — UCEC

Explore this box plot interactively →