HSP90AA1

Across TCGA cell cohorts, HSP90AA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,638 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HSP90AA1-associated GO terms across cancer lineages are DNA-templated DNA replication, Positive regulation of chromosome condensation, and DNA-templated DNA replication maintenance of fidelity. Each is linked with HSP90AA1 in more than 18 cancer types. Because this analysis shows association rather than direction, both HSP90AA1-to-partner and partner-to-HSP90AA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by HSP90AA1-low versus HSP90AA1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HSP90AA1→partner) and Y-score (partner→HSP90AA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA-templated DNA replication →	+0.155	+1.279	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.244	+1.834	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.089	+1.179	<.001	<.001	3	17
OESOPHAGUS	DNA replication →	+0.140	+1.279	<.001	<.001	2	18
OESOPHAGUS	DNA replication checkpoint signaling →	+0.211	+1.227	<.001	.001	3	17
URINARY_TRACT	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.104	+1.056	.001	.005	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,638 associations by consensus.

DNA-templated DNA replication by HSP90AA1 expression — OESOPHAGUS

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